Studies on Pseudorabies (infectious Bulbar

In England in 1930, using a strain of Aujeszky virus, 1 I was unable by intracerebral or intramuscular inoculation to secure infection of a rhesus monkey. Remlinger and Bailly (1933) also recorded failure with another species--Inuus ecaudatus. With the Iowa strain of pseudorabies virus, and with an Hungarian strain, ~ intracerebral injection at Princeton (1932) was successful in each of 5 cases. Inoculation by other routes met with less success. Intrasciatic inoculation accompanied by mild trauma (Hurst, 1930), and often by ligature of the nerve between the site of deposition of infective material and the point of entry of the needle (to prevent leakage), gave very inconstant results. Of 12 animals so inoculated with highly virulent rabbit virus, 2 only developed symptoms; the remainder were inoculated a second time in the nerve of the opposite